Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 5/20 | 0.40 |
| ▸ | CDK8 | P49336 | 5/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865685 | 0.94 | CLK2 (0.43) | PAK1KDM4ECCNCCDK8CA12 | |
| SCHEMBL13865716 | 0.91 | PAK1 (0.42) | PAK1KDM4ECCNCCDK8CA12 | |
| SCHEMBL13865711 | 0.85 | DRD2 (0.45) | PAK1KDM4ECCNCCDK8CA12 | |
| SCHEMBL13865723 | 0.84 | CCNC (0.43) | PAK1KDM4ECCNCCDK8CA12 | |
| SCHEMBL13865717 | 0.83 | PAK1 (0.46) | PAK1KDM4ECCNCCDK8CA12 | |
| SCHEMBL13865714 | 0.82 | TRPV1 (0.43) | PAK1KDM4ECA12CA1CA2 | |
| SCHEMBL13865715 | 0.82 | TRPV1 (0.54) | PAK1KDM4ESIGMAR1TRPV1P2RY1 | |
| SCHEMBL13865725 | 0.82 | TRPV1 (0.47) | PAK1KDM4ESIGMAR1CLK2GSK3A | |
| SCHEMBL13865719 | 0.79 | TRPV1 (0.44) | PAK1KDM4ETRPV1TRPM8 | |
| SCHEMBL13865722 | 0.77 | TRPV1 (0.45) | PAK1KDM4ECCNCCDK8CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |