Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865724 | 0.88 | PAK1 (0.46) | TRPV1PAK1KDM4EEPHX2SIGMAR1 | |
| SCHEMBL13865685 | 0.85 | CLK2 (0.43) | TRPV1PAK1KDM4EEPHX2SIGMAR1 | |
| SCHEMBL13865717 | 0.84 | PAK1 (0.46) | TRPV1PAK1KDM4ESIGMAR1 | |
| SCHEMBL13865713 | 0.82 | PAK1 (0.41) | TRPV1PAK1KDM4EP2RY1SIGMAR1 | |
| SCHEMBL13865715 | 0.81 | TRPV1 (0.54) | TRPV1PAK1KDM4EEPHX2RBP4 | |
| SCHEMBL13865716 | 0.80 | PAK1 (0.42) | TRPV1PAK1KDM4ESIGMAR1CLK2 | |
| SCHEMBL13870115 | 0.78 | PAK1 (0.49) | TRPV1PAK1KDM4EEPHX2SIGMAR1 | |
| SCHEMBL13865722 | 0.78 | TRPV1 (0.45) | TRPV1PAK1KDM4ESIGMAR1 | |
| SCHEMBL13865684 | 0.78 | CYP2C9 (0.49) | TRPV1PAK1KDM4EKIT | |
| SCHEMBL13865719 | 0.78 | TRPV1 (0.44) | TRPV1PAK1KDM4EEPHX2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |