Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865725 | 0.88 | TRPV1 (0.47) | PAK1SIGMAR1KDM4EEPHX2TRPV1 | |
| SCHEMBL13865717 | 0.86 | PAK1 (0.46) | PAK1SIGMAR1KDM4EEPHX1CA12 | |
| SCHEMBL13865720 | 0.86 | PAK1 (0.50) | PAK1SIGMAR1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL13865722 | 0.85 | TRPV1 (0.45) | PAK1SIGMAR1KDM4ECNR1CA12 | |
| SCHEMBL13870115 | 0.80 | PAK1 (0.49) | PAK1SIGMAR1KDM4EMALT1EPHX2 | |
| SCHEMBL13865684 | 0.78 | CYP2C9 (0.49) | PAK1KDM4ESMN1; SMN2TRPV1 | |
| SCHEMBL13865723 | 0.78 | CCNC (0.43) | PAK1SIGMAR1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL13865712 | 0.78 | PAK1 (0.46) | PAK1KDM4ESMN1; SMN2TRPV1 | |
| SCHEMBL13865685 | 0.76 | CLK2 (0.43) | PAK1SIGMAR1KDM4EEPHX2EPHX1 | |
| SCHEMBL13865715 | 0.76 | TRPV1 (0.54) | PAK1SIGMAR1KDM4EEPHX2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |