Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 7/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | PAK3 | O75914 | 1/20 | 0.38 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865721 | 0.89 | PAK1 (0.47) | PAK1TRPV1KITTRPM8PAK3 | |
| SCHEMBL13865718 | 0.88 | TRPV1 (0.47) | PAK1TRPV1KITTRPM8PAK3 | |
| SCHEMBL13865712 | 0.87 | PAK1 (0.46) | PAK1TRPV1KITTRPM8PAK3 | |
| SCHEMBL13865684 | 0.81 | CYP2C9 (0.49) | PAK1TRPV1KITTRPM8MAPT | |
| SCHEMBL13865714 | 0.81 | TRPV1 (0.43) | PAK1TRPV1KITTRPM8 | |
| SCHEMBL13865715 | 0.79 | TRPV1 (0.54) | PAK1TRPV1KIT | |
| SCHEMBL13865711 | 0.78 | DRD2 (0.45) | PAK1TRPV1TRPM8 | |
| SCHEMBL13865722 | 0.77 | TRPV1 (0.45) | PAK1TRPV1CNR1 | |
| SCHEMBL13865716 | 0.75 | PAK1 (0.42) | PAK1TRPV1TRPM8 | |
| SCHEMBL13870115 | 0.75 | PAK1 (0.49) | PAK1TRPV1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |