Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 20/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13867616 | 0.89 | CCR3 (0.38) | CCR3 | |
| SCHEMBL3889004 | 0.84 | CCR3 (0.37) | CCR3 | |
| SCHEMBL13867614 | 0.84 | CCR3 (0.37) | CCR3 | |
| SCHEMBL3889008 | 0.84 | CCR3 (0.37) | CCR3 | |
| SCHEMBL3879488 | 0.80 | CCR3 (0.48) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL7119177 | 0.80 | CCR3 (0.48) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL3884479 | 0.80 | CCR3 (0.69) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL3881530 | 0.80 | CCR3 (0.69) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL3878201 | 0.79 | CCR3 (0.70) | CCR3CYP2D6CXCR1CXCR2CCR1 | |
| SCHEMBL13867671 | 0.79 | HDAC6 (0.41) | CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514430-B2 | Piperizinones as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-04-07 | — | — | US | disclosed |