Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 16/20 | 0.48 |
| ▸ | CASP3 | P42574 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879488 | 1.00 | CCR3 (0.48) | CCR3CASP3CTSLCTSBCTSS | |
| SCHEMBL3886795 | 0.95 | CTSB (0.45) | CCR3CASP3CTSLCTSBCTSS | |
| SCHEMBL3886799 | 0.95 | CTSB (0.45) | CCR3CASP3CTSLCTSBCTSS | |
| SCHEMBL3878046 | 0.83 | HDAC6 (0.46) | CCR3CASP3CTSLCTSBCTSS | |
| SCHEMBL7112217 | 0.83 | HDAC6 (0.46) | CCR3CASP3CTSLCTSBCTSS | |
| SCHEMBL3881417 | 0.83 | CCR3 (0.43) | CCR3CASP3CTSLCTSBCTSS | |
| SCHEMBL13867601 | 0.80 | CCR3 (0.43) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL3881200 | 0.80 | CCR3 (0.57) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL3881197 | 0.80 | CCR3 (0.57) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL3881565 | 0.80 | CCR3 (0.57) | CCR3CYP2D6DRD2SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024401-A2 | PIPERIZINONES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |