Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | CCR3 | P51677 | 14/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13867668 | 0.84 | HDAC6 (0.41) | HDAC6HDAC1HDAC8OPRK1 | |
| SCHEMBL3878037 | 0.84 | HDAC6 (0.41) | HDAC6HDAC1HDAC8OPRK1 | |
| SCHEMBL3878033 | 0.84 | HDAC6 (0.41) | HDAC6HDAC1HDAC8OPRK1 | |
| SCHEMBL7112217 | 0.80 | HDAC6 (0.46) | HDAC6HDAC1HDAC8OPRK1CCR3 | |
| SCHEMBL3878046 | 0.80 | HDAC6 (0.46) | HDAC6HDAC1HDAC8OPRK1CCR3 | |
| SCHEMBL3885462 | 0.80 | CCR3 (0.63) | CCR3 | |
| SCHEMBL13867601 | 0.79 | CCR3 (0.43) | CCR3 | |
| SCHEMBL3891784 | 0.79 | CCR3 (0.66) | CCR3 | |
| SCHEMBL3888971 | 0.77 | CCR3 (0.66) | CCR3 | |
| SCHEMBL3889303 | 0.77 | CCR3 (0.66) | CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514430-B2 | Piperizinones as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-04-07 | — | — | US | disclosed |