Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 6/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878046 | 1.00 | HDAC6 (0.46) | HDAC6HDAC1HDAC8TACR2CCR3 | |
| SCHEMBL3879488 | 0.83 | CCR3 (0.48) | CCR3CTSBCTSSCTSKCTSL | |
| SCHEMBL7119177 | 0.83 | CCR3 (0.48) | CCR3CTSBCTSSCTSKCTSL | |
| SCHEMBL13867671 | 0.80 | HDAC6 (0.41) | HDAC6HDAC1HDAC8CCR3OPRK1 | |
| SCHEMBL13877111 | 0.78 | TACR2 (0.46) | HDAC6HDAC1HDAC8TACR2NPSR1 | |
| SCHEMBL3886795 | 0.77 | CTSB (0.45) | CCR3CTSBCTSSCTSKCTSL | |
| SCHEMBL3886799 | 0.77 | CTSB (0.45) | CCR3CTSBCTSSCTSKCTSL | |
| SCHEMBL3891784 | 0.77 | CCR3 (0.66) | CCR3 | |
| SCHEMBL3885462 | 0.76 | CCR3 (0.63) | CCR3 | |
| SCHEMBL3881417 | 0.76 | CCR3 (0.43) | CCR3CTSBCTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024401-A2 | PIPERIZINONES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |