Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.46 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21294997 | 1.00 | CHRM5 (0.53) | CHRM5NPC1RAB9AAPEX1NQO2 | |
| SCHEMBL15177199 | 0.82 | CHRM5 (0.57) | CHRM5NPC1RAB9AAPEX1MAPT | |
| SCHEMBL28255839 | 0.82 | NQO2 (0.43) | NPC1RAB9ANQO2MAPTPOLB | |
| SCHEMBL28254766 | 0.76 | MEN1 (0.40) | NPC1RAB9ANQO2MAPTPOLB | |
| SCHEMBL25731888 | 0.75 | CHRM5 (0.68) | CHRM5NPC1RAB9AMAPTPOLB | |
| SCHEMBL28255841 | 0.74 | GFER (0.65) | NPC1RAB9ANQO2MAPTPOLB | |
| SCHEMBL25731885 | 0.73 | CHRM5 (0.66) | CHRM5NPC1RAB9AMAPTKMT2A | |
| SCHEMBL5593276 | 0.73 | NQO2 (0.87) | NPC1APEX1NQO2POLBKMT2A | |
| SCHEMBL5593274 | 0.73 | NQO2 (0.87) | NPC1APEX1NQO2POLBKMT2A | |
| SCHEMBL28621063 | 0.72 | MAPT (0.56) | NPC1RAB9ANQO2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531669-B2 | Methods for treating neural disorders and conditions, and compounds useful therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2009-05-12 | — | — | US | disclosed |