Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13869668 | 0.88 | SIRT2 (0.36) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869584 | 0.85 | MAPT (0.35) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869780 | 0.85 | ALDH1A1 (0.34) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869731 | 0.84 | SIRT2 (0.38) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869280 | 0.84 | SIRT2 (0.42) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869405 | 0.80 | SIRT2 (0.34) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869617 | 0.78 | KDM4E (0.44) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869270 | 0.78 | MAOB (0.44) | ALDH1A1KDM4EMAPTMEN1POLB | |
| SCHEMBL13869378 | 0.77 | KDM4E (0.45) | SIRT2SIRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL13869313 | 0.76 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514158-B2 | Coumarin compound | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-04-07 | — | — | US | disclosed |
| US-7514158-B2 | Coumarin compound | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-04-07 | — | — | US | disclosed |