Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13869668 | 0.85 | SIRT2 (0.36) | SIRT2SIRT1KDM4EALDH1A1MAPT | |
| SCHEMBL13869626 | 0.84 | SIRT2 (0.36) | SIRT2SIRT1KDM4EALDH1A1MAPT | |
| SCHEMBL13869780 | 0.84 | ALDH1A1 (0.34) | SIRT2SIRT1KDM4EALDH1A1MAPT | |
| SCHEMBL13869731 | 0.81 | SIRT2 (0.38) | SIRT2SIRT1KDM4EALDH1A1MAPT | |
| SCHEMBL13869584 | 0.81 | MAPT (0.35) | SIRT2SIRT1KDM4EALDH1A1MAPT | |
| SCHEMBL13869827 | 0.80 | MAPT (0.43) | SIRT2SIRT1KDM4EALDH1A1MAPT | |
| SCHEMBL13869270 | 0.80 | MAOB (0.44) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL13869313 | 0.78 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL13869405 | 0.78 | SIRT2 (0.34) | SIRT2SIRT1KDM4EALDH1A1MAPT | |
| SCHEMBL13869554 | 0.77 | KDM4E (0.50) | SIRT2SIRT1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514158-B2 | Coumarin compound | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-04-07 | — | — | US | disclosed |
| US-7514158-B2 | Coumarin compound | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-04-07 | — | — | US | disclosed |