Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13176432 | 0.89 | ALDH1A1 (0.42) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2926919 | 0.88 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2921596 | 0.87 | POLB (0.44) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2920448 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2926159 | 0.83 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2917209 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL3031226 | 0.81 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2925273 | 0.79 | HSD11B1 (0.41) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2925815 | 0.79 | HSD11B1 (0.48) | ALDH1A1KDM4EMAPTPOLBMEN1 | |
| SCHEMBL2924576 | 0.79 | MAPT (0.67) | ALDH1A1KDM4EMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |