Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 6/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13869825 | 0.87 | MAPT (0.62) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869702 | 0.87 | MAPT (0.46) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869762 | 0.85 | EP300 (0.45) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869811 | 0.80 | MAPT (0.44) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869651 | 0.80 | MAPT (0.48) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869826 | 0.80 | CYP19A1 (0.65) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869488 | 0.79 | CYP19A1 (0.64) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869289 | 0.78 | ALDH1A1 (0.72) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869603 | 0.77 | MAPT (0.41) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13869582 | 0.77 | MAPT (0.53) | MAPTALDH1A1KDM4ESMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514158-B2 | Coumarin compound | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-04-07 | — | — | US | disclosed |
| US-7514158-B2 | Coumarin compound | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-04-07 | — | — | US | disclosed |