Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926656 | 0.91 | HSD11B1 (0.48) | HSD11B1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL13869863 | 0.86 | CDKN1A (0.50) | SIRT2PDE4BNPC1POLBRAB9A | |
| SCHEMBL2924396 | 0.76 | TP53 (0.58) | HSD11B1NPC1POLBRAB9AMEN1 | |
| SCHEMBL2923793 | 0.75 | HSD11B1 (0.48) | HSD11B1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2916406 | 0.74 | MAPT (0.52) | NPC1POLBRAB9ABLMMEN1 | |
| SCHEMBL3984885 | 0.73 | MAPT (0.49) | HSD11B1POLBMEN1KMT2A | |
| SCHEMBL1820563 | 0.73 | HSD11B1 (0.46) | HSD11B1POLBHSD17B10MEN1KMT2A | |
| SCHEMBL2925815 | 0.72 | HSD11B1 (0.48) | HSD11B1POLBRAB9ABLMHSD17B10 | |
| SCHEMBL1818757 | 0.70 | HSD11B1 (0.47) | HSD11B1HSD17B10MEN1KMT2ALMNA | |
| SCHEMBL4068166 | 0.70 | MAPT (0.55) | POLBMEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |