Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | CDKN1A | P38936 | 3/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924396 | 0.91 | TP53 (0.58) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2926345 | 0.86 | CDKN1A (0.56) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL2925650 | 0.85 | CDKN1A (0.56) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL13869863 | 0.84 | CDKN1A (0.50) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL2920423 | 0.83 | CDKN1A (0.57) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL2918432 | 0.83 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL2915153 | 0.81 | NPC1 (0.60) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL2925167 | 0.80 | CDKN1A (0.54) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL2922685 | 0.80 | CDKN1A (0.53) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL2923793 | 0.79 | HSD11B1 (0.48) | MAPTALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828197-B1 | NOVEL SUBSTITUTED THIOPHENEPYRIMIDINONE DERIVATIVES AS INHIBITORS OF 17ß-HYDROXYSTEROID DEHYDROGENASE | SOLVAY PHARM GMBH (DE) | 2009-05-13 | — | — | EP | disclosed |