Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | FHIT | P49789 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848534 | 0.88 | MAPT (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL13886690 | 0.84 | MAPT (0.59) | MAPTLMNAALOX12KDM4EALDH1A1 | |
| SCHEMBL13869904 | 0.81 | SMN1; SMN2 (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL13869871 | 0.75 | MAPT (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3984848 | 0.71 | MAPT (0.67) | MAPTFHITALDH1A1GAASMN1; SMN2 | |
| SCHEMBL29266100 | 0.69 | NR1H2 (0.59) | CA12CA1CA2CA7CA9 | |
| SCHEMBL13848532 | 0.69 | MAPT (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11688995 | 0.69 | TSHR (0.46) | CA12CA1CA2CA7CA9 | |
| SCHEMBL27853304 | 0.68 | CA12 (0.54) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3990785 | 0.68 | KMT2A (0.69) | MAPTLMNAALOX12KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |