Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | FHIT | P49789 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848534 | 0.87 | MAPT (0.48) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13848532 | 0.81 | MAPT (0.49) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13869870 | 0.75 | MAPT (0.51) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13869967 | 0.75 | CA12 (0.43) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13886690 | 0.72 | MAPT (0.59) | MAPTGAAMEN1KMT2ATSHR | |
| SCHEMBL2925906 | 0.71 | TSHR (0.67) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL3984848 | 0.68 | MAPT (0.67) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13869904 | 0.68 | SMN1; SMN2 (0.51) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL31460105 | 0.67 | MAPT (0.53) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL223094 | 0.67 | ALDH1A1 (1.00) | MAPTGAAMEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |
| US-7465739-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-16 | — | — | US | disclosed |