Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848532 | 0.88 | MAPT (0.49) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL13886692 | 0.85 | MAPT (0.60) | SMN1; SMN2MAPTALDH1A1HPGDMEN1 | |
| SCHEMBL13869967 | 0.81 | CA12 (0.43) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL13869878 | 0.76 | MAPT (0.49) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL3990578 | 0.72 | MAPT (0.64) | SMN1; SMN2TDP1MAPTALDH1A1HPGD | |
| SCHEMBL13848534 | 0.69 | MAPT (0.48) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL6395023 | 0.69 | SMN1; SMN2 (0.60) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL3902129 | 0.69 | ALDH1A1 (0.61) | SMN1; SMN2TDP1MAPTALDH1A1HPGD | |
| SCHEMBL13343534 | 0.69 | MAPT (0.64) | SMN1; SMN2TDP1MAPTALDH1A1HPGD | |
| SCHEMBL13869871 | 0.68 | MAPT (0.47) | SMN1; SMN2CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |