Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY5 | O95622 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.58 |
| ▸ | PI4KA | P42356 | 2/20 | 0.54 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.54 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | AHCY | P23526 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355770 | 0.86 | ADCY5 (0.57) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL6029347 | 0.85 | ADCY5 (0.65) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL13870051 | 0.85 | ADORA2A (0.69) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL6029039 | 0.84 | ADORA2A (0.69) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL13870064 | 0.82 | ADORA2A (0.71) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL14086581 | 0.81 | ADORA2A (0.69) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL9204975 | 0.79 | ADORA2A (0.64) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL4811419 | 0.78 | ADORA2A (0.72) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| Hydrochloric Acid SCHEMBL10339774 | 0.77 | ADORA2A (0.62) | ADCY5ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL11222112 | 0.77 | ADORA2A (0.80) | ADCY5ADORA2AADORA1ADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478653-B1 | MACROLIDES WITH ANTIBACTERIAL ACTIVITY | BASILEA PHARMACEUTICA AG (CH) | 2014-07-02 | — | — | EP | disclosed |
| US-7524823-B2 | Macrolides | BASILEA PHARMACEUTICA AG (CH) | 2009-04-28 | — | — | US | disclosed |
| US-7524823-B2 | Macrolides | BASILEA PHARMACEUTICA AG (CH) | 2009-04-28 | — | — | US | disclosed |
| US-7291602-B2 | 11,12-lactone bicyclolides | ENANTA PHARMACEUTICALS, INC. (US) | 2007-11-06 | — | — | US | disclosed |