Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 8/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32660139 | 0.86 | TDP1 (0.75) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL3084595 | 0.86 | TDP1 (0.75) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL3069742 | 0.86 | TDP1 (0.75) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL6442808 | 0.83 | TDP1 (1.00) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL19642850 | 0.82 | TDP1 (0.63) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL230330 | 0.80 | TDP1 (0.78) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL9814242 | 0.80 | TDP1 (0.84) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL30294105 | 0.80 | TDP1 (0.84) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| SCHEMBL3161153 | 0.80 | TDP1 (0.84) | TDP1LMNASMN1; SMN2HTTEGLN3 | |
| Bromide SCHEMBL10912945 | 0.79 | TDP1 (0.75) | TDP1LMNASMN1; SMN2HTTEGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524823-B2 | Macrolides | BASILEA PHARMACEUTICA AG (CH) | 2009-04-28 | — | — | US | disclosed |
| US-7524823-B2 | Macrolides | BASILEA PHARMACEUTICA AG (CH) | 2009-04-28 | — | — | US | disclosed |