Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A15 | Q9H2J7 | 14/20 | 0.39 |
| ▸ | HRH1 | P35367 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13888661 | 0.87 | SLC6A15 (0.53) | SLC6A15HRH1KCNH2MEN1NPC1 | |
| SCHEMBL13870561 | 0.77 | ALDH1A1 (0.46) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13870567 | 0.72 | KCNH2 (0.60) | HRH1KCNH2HTR2AFNTAFNTB | |
| SCHEMBL13870568 | 0.71 | KCNH2 (0.49) | SLC6A15HRH1KCNH2MEN1NPC1 | |
| SCHEMBL13870466 | 0.70 | SLC6A15 (0.62) | SLC6A15HRH1KCNH2MEN1NPC1 | |
| SCHEMBL13870569 | 0.69 | HRH1 (0.43) | SLC6A15HRH1KCNH2MEN1LMNA | |
| SCHEMBL13870542 | 0.68 | HRH1 (0.52) | SLC6A15HRH1KCNH2MEN1NPC1 | |
| SCHEMBL12065129 | 0.66 | HRH1 (0.61) | SLC6A15HRH1KCNH2MEN1NPC1 | |
| SCHEMBL10843503 | 0.65 | ALDH1A1 (0.61) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13870522 | 0.65 | HRH1 (0.53) | SLC6A15HRH1KCNH2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524864-B2 | Methods of treating sleep disorders | HYPNION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7482460-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7411069-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7355042-B2 | Treatment of CNS disorders using CNS target modulators | HYPNION, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7326721-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |