Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919412 | 0.84 | ALDH1A1 (0.73) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL13870585 | 0.82 | CYP2C9 (0.49) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL13870586 | 0.82 | CYP2C9 (0.51) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2918809 | 0.81 | ALDH1A1 (0.70) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL14369638 | 0.79 | KDM4E (0.68) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL18353617 | 0.77 | ALDH1A1 (0.64) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL10563617 | 0.77 | ALDH1A1 (0.58) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL29838942 | 0.76 | ALDH1A1 (0.63) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL12266478 | 0.76 | PDE4D (0.73) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL20142756 | 0.75 | ALDH1A1 (0.71) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521471-B2 | 4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof | SANOFI-AVENTIS (FR) | 2009-04-21 | — | — | US | disclosed |
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | CBR3, CNR1, CNR2 | ALDH1A1 742/4885CYP3A4 87/4885CYP2C9 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.