Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13870524 | 0.83 | ALDH1A1 (0.67) | ALDH1A1MAPTRAB9ASMN1; SMN2AKR1B1 | |
| SCHEMBL13870503 | 0.77 | MAPK14 (0.59) | ALDH1A1MAPTRAB9ASMN1; SMN2AKR1B1 | |
| SCHEMBL13870592 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8798148 | 0.76 | ALDH1A1 (0.68) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2760390 | 0.75 | ALDH1A1 (0.54) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10373496 | 0.73 | ALDH1A1 (0.63) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8797635 | 0.72 | ALDH1A1 (0.62) | ALDH1A1MAPTRAB9ASMN1; SMN2AKR1B1 | |
| SCHEMBL15782103 | 0.72 | MAPK14 (0.52) | — | |
| SCHEMBL13870561 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPTRAB9ASMN1; SMN2AKR1B1 | |
| SCHEMBL10562210 | 0.72 | MAPT (0.60) | ALDH1A1MAPTRAB9ASMN1; SMN2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524864-B2 | Methods of treating sleep disorders | HYPNION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7482460-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7411069-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7326721-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-02-05 | — | — | US | disclosed |