Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248564 | 0.83 | MAPT (0.64) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 | |
| SCHEMBL13870503 | 0.79 | MAPK14 (0.59) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 | |
| SCHEMBL13870599 | 0.77 | ALDH1A1 (0.47) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 | |
| SCHEMBL8798148 | 0.77 | ALDH1A1 (0.68) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 | |
| SCHEMBL2760390 | 0.76 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 | |
| SCHEMBL7346929 | 0.74 | AKR1B1 (0.56) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 | |
| SCHEMBL15782103 | 0.73 | MAPK14 (0.52) | METAP1MAPK14MAOB | |
| SCHEMBL6208874 | 0.73 | HSD17B10 (0.52) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 | |
| SCHEMBL1467863 | 0.70 | MAPT (0.58) | ALDH1A1MAPTTDP1KDM4EGAA | |
| SCHEMBL8773544 | 0.70 | MMP12 (0.49) | ALDH1A1MAPTSMN1; SMN2RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524864-B2 | Methods of treating sleep disorders | HYPNION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7482460-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7411069-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7326721-B2 | Doxepin analogs and methods of use thereof | HYPNION, INC. (US) | 2008-02-05 | — | — | US | disclosed |