Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7443521 | 0.99 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL7564110 | 0.89 | KDM4E (0.82) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL14970474 | 0.88 | KDM4E (0.75) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL7398924 | 0.86 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL7399802 | 0.86 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL7396432 | 0.86 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| Hydrochloric Acid SCHEMBL7594910 | 0.85 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| Hydrochloric Acid SCHEMBL7395361 | 0.85 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL9528149 | 0.79 | KDM4E (0.62) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 | |
| Hydrochloric Acid SCHEMBL2528505 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09504014-A | — | — | 1997-04-22 | — | — | JP | claimed |
| EP-0724578-A1 | AMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-08-07 | — | — | EP | claimed |
| WO-1995011240-A1 | AMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-04-27 | — | — | WO | claimed |
| EP-0724578-A1 | AMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011240-A1 | AMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-04-27 | — | — | WO | disclosed |