Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13874593 | 0.87 | PIK3CA (0.46) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL13874185 | 0.82 | MAPK14 (0.42) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL13874536 | 0.78 | NOTUM (0.40) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL3846792 | 0.78 | TGFBR1 (0.38) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL13874443 | 0.76 | PIK3CA (0.39) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL3847272 | 0.73 | PIK3CA (0.46) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL13874626 | 0.72 | MAPK14 (0.34) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL3848709 | 0.71 | PIK3CA (0.44) | PIK3CAPIK3R1MTOR | |
| SCHEMBL3847818 | 0.70 | PIK3CA (0.45) | PIK3CAPIK3R1MAPK14TGFBR1MTOR | |
| SCHEMBL3847367 | 0.69 | PIK3CA (0.42) | PIK3CAPIK3R1MAPK14TGFBR1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |