Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3852731 | 0.93 | PIK3CA (0.42) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL3846792 | 0.92 | TGFBR1 (0.38) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL3846674 | 0.85 | MAPK14 (0.41) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL3847272 | 0.81 | PIK3CA (0.46) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL3849288 | 0.80 | PTGS2 (0.37) | PIK3CAPIK3R1MAPK14TGFBR1FLT3 | |
| SCHEMBL3847230 | 0.79 | PTGS2 (0.36) | PIK3CAPIK3R1MAPK14TGFBR1FLT3 | |
| SCHEMBL3853605 | 0.78 | FLT3 (0.39) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL3846502 | 0.78 | PIK3CA (0.40) | PIK3CAMTORPIK3CBMAPK14TGFBR1 | |
| SCHEMBL3847708 | 0.78 | PIK3R1 (0.37) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL3848109 | 0.77 | FLT3 (0.40) | MAPK14TGFBR1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |