Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13876132 | 0.84 | DPP4 (0.39) | DOT1LALDH1A1NPSR1TSHRTHRB | |
| SCHEMBL13876125 | 0.82 | BTK (0.48) | DPP4 | |
| SCHEMBL13866874 | 0.74 | DPP4 (0.42) | ALDH1A1NPSR1TSHRHSD17B10HRH4 | |
| SCHEMBL13866879 | 0.72 | DPP4 (0.48) | DPP4 | |
| Trifluoroacetic Acid SCHEMBL3879683 | 0.67 | DPP4 (0.43) | DPP4 | |
| Trifluoroacetic Acid SCHEMBL3877706 | 0.67 | DPP4 (0.39) | HRH4DPP4POLBCHRNB2ADRA1D | |
| SCHEMBL13875830 | 0.66 | CHRNB2 (0.49) | ALDH1A1NPSR1TSHRHSD17B10KDM4E | |
| SCHEMBL13822690 | 0.66 | BTK (0.49) | DPP4 | |
| SCHEMBL12517290 | 0.66 | BTK (0.49) | DPP4 | |
| SCHEMBL21895399 | 0.64 | CHRNB2 (0.54) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524847-B2 | Fused 1,3-dihydro-imidazole ring compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-04-28 | — | — | US | disclosed |