Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 2/20 | 0.40 |
| ▸ | SKP1 | P63208 | 2/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3885644 | 0.87 | KIT (0.50) | KITMAP4K4KCNH2MAPTACHE | |
| SCHEMBL2923711 | 0.78 | KIT (0.51) | KITMAP4K4KCNH2MAPTACHE | |
| SCHEMBL5849252 | 0.77 | KIT (0.56) | KITMAP4K4KCNH2MAPTACHE | |
| SCHEMBL2272116 | 0.76 | KIT (0.62) | KITMAPTLMNAHTT | |
| SCHEMBL15689398 | 0.75 | KIT (0.70) | KITMAP4K4KCNH2ACHECNR1 | |
| SCHEMBL13875886 | 0.75 | KCNH2 (0.44) | KITMAP4K4KCNH2CNR1CNR2 | |
| SCHEMBL30225432 | 0.74 | KIT (0.58) | KITMAP4K4MAPTACHECKS1B | |
| SCHEMBL1031240 | 0.74 | KIT (0.58) | KITMAP4K4MAPTACHECKS1B | |
| SCHEMBL17282985 | 0.74 | KIT (0.69) | KITMAP4K4KCNH2ACHECNR1 | |
| SCHEMBL23932490 | 0.74 | KIT (0.54) | KITMAP4K4MAPTCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524847-B2 | Fused 1,3-dihydro-imidazole ring compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-04-28 | — | — | US | disclosed |