Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388899 | 0.84 | KDM4E (0.58) | HTR1AMEN1KMT2AATMKDM4E | |
| SCHEMBL1387370 | 0.78 | MAPT (0.54) | HTR1AKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL8858351 | 0.77 | HTR1A (0.49) | HTR1AKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL8858353 | 0.77 | HTR1A (0.49) | HTR1AKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL238334 | 0.72 | MEN1 (0.66) | HTR1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5474628 | 0.71 | HTR1A (1.00) | HTR1A | |
| Hydrochloric Acid SCHEMBL19066024 | 0.71 | MEN1 (0.65) | HTR1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1388014 | 0.70 | DRD4 (0.65) | HTR1AMEN1KMT2ADRD2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL29662083 | 0.69 | SIGMAR1 (0.56) | HTR1AMEN1KMT2AATMKDM4E | |
| SCHEMBL5542167 | 0.69 | SIGMAR1 (0.56) | HTR1AMEN1KMT2AATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09512542-A | — | — | 1997-12-16 | — | — | JP | claimed |
| EP-0757686-A1 | BENZOFURAN DERIVATIVES AS D 4? RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-02-12 | — | — | EP | claimed |
| WO-1995029911-A1 | BENZOFURAN DERIVATIVES AS D4 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-09 | — | — | WO | claimed |
| US-5665722-A | Benzofuran derivatives as D4 receptor antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| EP-0757686-A1 | BENZOFURAN DERIVATIVES AS D 4? RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029911-A1 | BENZOFURAN DERIVATIVES AS D4 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-09 | — | — | WO | disclosed |