Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13879079 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL13879188 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL10211081 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL14395329 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL20211423 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL9344214 | 0.79 | ALDH1A1 (0.46) | ALDH1A1TDP1LMNAKDM4ECYP1A2 | |
| SCHEMBL10154164 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL16020893 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL16020817 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E | |
| SCHEMBL17613405 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1TDP1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048152-A1 | FUSED RING SPIROKETAL DERIVATIVE AND USE THEREOF AS DRUG FOR TREATING DIABETES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-04-15 | — | — | EP | disclosed |