Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | RXRA | P19793 | 1/20 | 0.61 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.59 |
| ▸ | CTSV | O60911 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28662878 | 0.87 | NPSR1 (0.58) | HTTLMNARXRAMRGPRX4CTSV | |
| SCHEMBL1387886 | 0.86 | ABCB1 (0.58) | HTTLMNARXRAMRGPRX4ABCB1 | |
| SCHEMBL11770598 | 0.83 | MRGPRX4 (0.74) | HTTLMNAMRGPRX4ALDH1A1HPGD | |
| SCHEMBL12963323 | 0.83 | ABCB1 (0.73) | HTTLMNARXRAMRGPRX4ABCB1 | |
| SCHEMBL1388037 | 0.82 | RXRA (0.60) | HTTRXRAABCB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1388008 | 0.82 | MRGPRX4 (0.59) | MRGPRX4ABCB1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL28346227 | 0.81 | RXRA (0.56) | HTTLMNARXRAMRGPRX4ALDH1A1 | |
| SCHEMBL5839701 | 0.81 | ABCB1 (0.58) | HTTLMNARXRAMRGPRX4ABCB1 | |
| SCHEMBL112903 | 0.80 | SGMS2 (0.66) | HTTLMNAALDH1A1NPC1FOLH1 | |
| SCHEMBL29433417 | 0.80 | SGMS2 (0.66) | HTTLMNAALDH1A1NPC1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09500883-A | — | — | 1997-01-28 | — | — | JP | claimed |
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | claimed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | claimed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | claimed |