Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472333 | 0.90 | PKM (0.49) | DHFR | |
| SCHEMBL11286352 | 0.85 | DHFR (0.68) | DHFR | |
| SCHEMBL5669553 | 0.83 | CSF1R (0.49) | CSF1RNTRK2DHFR | |
| SCHEMBL1317138 | 0.83 | DHFR (0.54) | DHFR | |
| SCHEMBL2449388 | 0.81 | DHFR (0.52) | DHFR | |
| SCHEMBL3447051 | 0.81 | CSF1R (0.47) | CSF1RNTRK2 | |
| SCHEMBL13650292 | 0.77 | CSF1R (0.50) | CSF1RNTRK2DHFR | |
| SCHEMBL2453594 | 0.77 | — | — | |
| SCHEMBL23472442 | 0.75 | TLR8 (0.52) | — | |
| SCHEMBL2450159 | 0.74 | DHFR (0.59) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H08504798-A | — | — | 1996-05-21 | — | — | JP | claimed |
| EP-0674627-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-10-04 | — | — | EP | claimed |
| WO-1994014780-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-07 | — | — | WO | claimed |
| EP-0674627-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014780-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |