Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | TYMP | P19971 | 2/20 | 0.42 |
| ▸ | UNG | P13051 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108830 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL21328426 | 0.81 | TSHR (0.53) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL18130011 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL18130013 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL13883659 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL14123250 | 0.76 | SMN1; SMN2 (0.71) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL6066218 | 0.74 | PDPK1 (0.54) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL2959182 | 0.74 | GPR84 (0.50) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL2961220 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT | |
| SCHEMBL22640015 | 0.72 | HSD17B10 (0.75) | SMN1; SMN2HSD17B10TSHRL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049018-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |