Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885685 | 0.82 | RPS6KB1 (0.38) | CREBBPPTGER4ALDH1A1KDM4E | |
| SCHEMBL12294399 | 0.81 | HSP90AA1 (0.43) | CREBBPHSP90AA1HSP90AB1PTGER4HSP90B1 | |
| SCHEMBL13885493 | 0.80 | CREBBP (0.40) | CREBBPHSP90AA1HSP90AB1PTGER4ALDH1A1 | |
| SCHEMBL2425635 | 0.79 | HSP90AA1 (0.52) | CREBBPHSP90AA1HSP90AB1PTGER4HSP90B1 | |
| SCHEMBL2429883 | 0.78 | IDO1 (0.51) | HSP90AA1HSP90AB1JAK3KDM4EKMT2A | |
| SCHEMBL12294390 | 0.77 | CREBBP (0.44) | CREBBPHSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL2429022 | 0.75 | ACKR3 (0.50) | KDM4E | |
| SCHEMBL13450266 | 0.71 | HSP90AA1 (0.51) | CREBBPHSP90AA1HSP90AB1PTGER4HSP90B1 | |
| SCHEMBL2429456 | 0.71 | PTGER4 (0.67) | HSP90AA1HSP90AB1PTGER4TRAP1ALDH1A1 | |
| SCHEMBL3972333 | 0.70 | HSP90AA1 (0.43) | CREBBPHSP90AA1HSP90AB1PTGER4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |