SCHEMBL3972333

SCHEMBL3972333

NC(=O)c1ccc(C(=O)O)cc1NCCC1CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.43
HSP90AB1 P08238 5/20 0.43
PTGER4 P35408 1/20 0.39
CREBBP Q92793 2/20 0.39
PIM1 P11309 1/20 0.38
PIM2 Q9P1W9 1/20 0.38
CYP2C9 P11712 1/20 0.38
LIPC P11150 1/20 0.38
LIPG Q9Y5X9 1/20 0.38
ALDH1A1 P00352 3/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.38
THRB P10828 1/20 0.38
HPGD P15428 1/20 0.38
HTT P42858 1/20 0.38
GFER P55789 1/20 0.38
PLEC Q15149 1/20 0.38
PPM1D O15297 1/20 0.37
CDC7 O00311 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2425635 0.86 HSP90AA1 (0.52) HSP90AA1HSP90AB1PTGER4CREBBPLIPC
SCHEMBL2425639 0.80 HCAR3 (0.55) PTGER4CREBBPALDH1A1MAPTKDM4E
SCHEMBL3980322 0.80 HSP90AA1 (0.40) HSP90AA1HSP90AB1PIM1PIM2CYP2C9
SCHEMBL2424146 0.80 ALDH1A1 (0.40) PTGER4ALDH1A1MAPTKDM4EGAA
SCHEMBL2427920 0.78 HCAR3 (0.56) PTGER4ALDH1A1MAPTKDM4EGAA
SCHEMBL13450266 0.77 HSP90AA1 (0.51) HSP90AA1HSP90AB1PTGER4CREBBPLIPC
SCHEMBL2432061 0.77 MAPT (0.62) PTGER4ALDH1A1MAPTKDM4EGAA
SCHEMBL3141041 0.77 HCAR3 (0.57) ALDH1A1MAPTKDM4EGAATHRB
SCHEMBL2429456 0.77 PTGER4 (0.67) HSP90AA1HSP90AB1PTGER4ALDH1A1MAPT
SCHEMBL2423994 0.76 ALDH1A1 (0.40) PTGER4ALDH1A1MAPTKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074120-A1 TROPANE COMPOUNDS Exelixis, Inc. (US) 2009-07-01 EP disclosed
WO-2009055077-A1 TROPANE COMPOUNDS EXELIXIS, INC. (US) 2009-04-30 WO disclosed