Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 0.52 |
| ▸ | GSK3B | P49841 | 14/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13885698 | 1.00 | CDK2 (0.52) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL11931070 | 0.91 | CDK2 (0.54) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL13885181 | 0.91 | CDK2 (0.54) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL14528910 | 0.85 | CDK2 (0.47) | CDK2GSK3BMAPKAPK2 | |
| SCHEMBL14528760 | 0.81 | CDK2 (0.46) | CDK2GSK3BCCNE1FLT3CHEK1 | |
| SCHEMBL13885689 | 0.80 | CDK2 (0.47) | CDK2GSK3BMAPKAPK2CCNE1FLT3 | |
| SCHEMBL13885686 | 0.80 | BCL6 (0.53) | CDK2GSK3BCCNE1FLT3CDK1 | |
| SCHEMBL13998510 | 0.79 | GSK3B (0.46) | CDK2GSK3BMAPKAPK2CCNE1 | |
| SCHEMBL13998539 | 0.79 | GSK3B (0.46) | CDK2GSK3BMAPKAPK2CCNE1 | |
| SCHEMBL13885679 | 0.79 | BCL6 (0.55) | CDK2GSK3BCCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514442-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |