Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 4/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887363 | 0.89 | ACACB (0.46) | DGAT1PTGESACACBMCHR1MAPK14 | |
| SCHEMBL13887369 | 0.88 | ACACB (0.45) | ACACBMCHR1 | |
| SCHEMBL13887314 | 0.87 | MCHR1 (0.44) | PTGESACACBMCHR1 | |
| SCHEMBL13887384 | 0.85 | MCHR1 (0.48) | ACACBMCHR1 | |
| SCHEMBL13887330 | 0.83 | MCHR1 (0.41) | DGAT1PTGESACACBMCHR1 | |
| SCHEMBL13887383 | 0.82 | MCHR1 (0.46) | DGAT1PTGESSOAT1KCNH2TRPV1 | |
| SCHEMBL13895112 | 0.82 | MCHR1 (0.41) | DGAT1SOAT1KCNH2NPBWR1DYRK1A | |
| SCHEMBL13887375 | 0.81 | MCHR1 (0.45) | DGAT1PTGESMCHR1 | |
| SCHEMBL13887336 | 0.80 | MCHR1 (0.40) | DGAT1PTGESACACBMCHR1 | |
| SCHEMBL13887332 | 0.80 | MCHR1 (0.41) | PTGESACACBMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524862-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-28 | — | — | US | disclosed |