Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887357 | 0.89 | MCHR1 (0.42) | MCHR1 | |
| SCHEMBL13887364 | 0.87 | MCHR1 (0.41) | MCHR1 | |
| SCHEMBL13887292 | 0.87 | MCHR1 (0.51) | MCHR1 | |
| SCHEMBL13887294 | 0.86 | NPC1 (0.52) | MCHR1 | |
| SCHEMBL13887339 | 0.85 | MCHR1 (0.48) | MCHR1 | |
| Trifluoroacetic Acid SCHEMBL4497060 | 0.85 | MCHR1 (0.46) | MCHR1 | |
| SCHEMBL13887380 | 0.85 | MCHR1 (0.55) | MCHR1 | |
| SCHEMBL13894861 | 0.82 | MCHR1 (0.47) | MCHR1DGAT1 | |
| SCHEMBL13887302 | 0.81 | MCHR1 (0.43) | MCHR1 | |
| SCHEMBL13887378 | 0.81 | DGAT1 (0.45) | MCHR1DGAT1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524862-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-28 | — | — | US | disclosed |