Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.48 |
| ▸ | ACACB | O00763 | 5/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887369 | 0.89 | ACACB (0.45) | MCHR1ACACBSCN10ACYP2D6CHRM1 | |
| SCHEMBL13887314 | 0.88 | MCHR1 (0.44) | MCHR1ACACBCYP2D6CHRM1HTR2A | |
| SCHEMBL13887363 | 0.88 | ACACB (0.46) | MCHR1ACACBSCN10AGRM5 | |
| SCHEMBL13887378 | 0.85 | DGAT1 (0.45) | MCHR1ACACB | |
| SCHEMBL13887380 | 0.82 | MCHR1 (0.55) | MCHR1ACACBCYP2D6CHRM1HTR2A | |
| SCHEMBL13887382 | 0.82 | MCHR1 (0.49) | MCHR1ACACBSCN10ACYP2D6CHRM1 | |
| SCHEMBL13895016 | 0.81 | MAPK1 (0.39) | PDGFRBPDGFRANPC1MAPTRAB9A | |
| SCHEMBL13887327 | 0.81 | MCHR1 (0.44) | MCHR1ACACBCYP2D6CHRM1HTR2A | |
| SCHEMBL13887332 | 0.80 | MCHR1 (0.41) | MCHR1ACACBCYP2D6CHRM1HTR2A | |
| SCHEMBL13887336 | 0.79 | MCHR1 (0.40) | MCHR1ACACBCYP2D6CHRM1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524862-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-28 | — | — | US | disclosed |