Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887364 | 0.89 | MCHR1 (0.41) | MCHR1GFERNPSR1CHRM1HTR2A | |
| SCHEMBL13887292 | 0.87 | MCHR1 (0.51) | MCHR1GFERCHRM1HTR2ACYP2D6 | |
| SCHEMBL13887357 | 0.87 | MCHR1 (0.42) | MCHR1GFERNPSR1CHRM1HTR2A | |
| SCHEMBL13887294 | 0.86 | NPC1 (0.52) | MCHR1GFERCHRM1HTR2ACYP2D6 | |
| SCHEMBL13887339 | 0.85 | MCHR1 (0.48) | MCHR1GFERCHRM1HTR2ACYP2D6 | |
| SCHEMBL13887375 | 0.85 | MCHR1 (0.45) | MCHR1 | |
| SCHEMBL13894874 | 0.82 | GFER (0.59) | GFERNPSR1ALDH1A1HTTBCHE | |
| SCHEMBL13887384 | 0.82 | MCHR1 (0.48) | MCHR1CHRM1HTR2ACYP2D6ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4497060 | 0.79 | MCHR1 (0.46) | MCHR1GFERCHRM1HTR2ACYP2D6 | |
| SCHEMBL13887295 | 0.79 | TRPC3 (0.55) | MCHR1GFERCHRM1HTR2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524862-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-28 | — | — | US | disclosed |