Leucine

Leucine

SCHEMBL138874

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.62
SLC1A2 P43004 7/20 0.50
SLC1A3 P43003 6/20 0.50
SLC1A1 P43005 7/20 0.47
GRIK1 P39086 11/20 0.41
GRIK2 Q13002 8/20 0.41
DPP4 P27487 1/20 0.37
DPP8 Q6V1X1 1/20 0.37
DPP9 Q86TI2 1/20 0.37
GRM1 Q13255 1/20 0.36
GRM2 Q14416 1/20 0.36
GRIA4 P48058 3/20 0.36
GRIK3 Q13003 3/20 0.36
GRIK5 Q16478 3/20 0.36
GRIA2 P42262 2/20 0.35
GRIA1 P42261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL28948522 1.00 SLC7A5 (0.62) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL692565 1.00 SLC7A5 (0.62) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL2408752 1.00 SLC7A5 (0.62) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL1863461 0.97 SLC7A5 (0.58) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL7759799 0.97 SLC7A5 (0.58) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL4294625 0.95 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL122271 0.95 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL3314487 0.95 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL18249997 0.95 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL1537205 0.95 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8840 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122064034-A Intelligent diversion purification control system for heat stable salt in amine liquid system 中国石油化工股份有限公司 2026-05-19 CN claimed
CN-122021250-A Knowledge decision supervision method for flood prevention in drainage basin 四川公用信息产业有限责任公司 2026-05-12 CN claimed
CN-119842425-A Natural gas desulfurization method and device 中国石油化工股份有限公司 2025-04-18 CN claimed
CN-118666702-A Modified multi-branched amine demulsifier and preparation method and application thereof 北京中科康仑能源科技有限公司 2024-09-20 CN claimed
CN-114595531-B Air inlet manifold design method based on double-stack flow distribution consistency 武汉雄韬氢雄燃料电池科技有限公司 2022-10-14 CN claimed
CN-114580124-A Design method for variable-section uniform air supply pipeline of rail transit vehicle 上海海洋大学 2022-06-03 CN claimed
CN-112083169-A Body fluid small molecule metabolic marker of zebra fish infected with Edwardsiella and application thereof 菏泽学院 2020-12-15 CN claimed
EP-2515920-B1 LOW-CALORIC HIGH-PROTEIN NUTRITIONAL COMPOSITION FOR THE STIMULATION OF MUSCLE PROTEIN SYNTHESIS NUTRICIA NV (NL) 2014-12-17 EP claimed
US-20030100100-A1 Insertional mutations in mycobacteria ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. 2003-05-29 US claimed
CN-122064034-A Intelligent diversion purification control system for heat stable salt in amine liquid system 中国石油化工股份有限公司 2026-05-19 CN disclosed
CN-122021250-A Knowledge decision supervision method for flood prevention in drainage basin 四川公用信息产业有限责任公司 2026-05-12 CN disclosed
US-12605459-B2 Protein-drug conjugates comprising camptothecin analogs and methods of use thereof REGENERON PHARMACEUTICALS, INC. (US) 2026-04-21 US disclosed
US-20250345773-A1 GLYCIDYL ETHER MODIFIED AMINE SORBENTS, SYSTEMS INCLUDING SORBENTS, AND METHODS USING THE SORBENTS GLOBAL THERMOSTAT OPERATIONS LLC (US) 2025-11-13 US disclosed
EP-4630149-A1 GLYCIDYL ETHER MODIFIED AMINE SORBENTS, SYSTEMS INCLUDING SORBENTS, AND METHODS USING THE SORBENTS Global Thermostat Operations, LLC (US) 2025-10-15 EP disclosed
WO-1992022326-A1 INSERTIONAL MUTATIONS IN MYCOBACTERIA ALBERT EINSTEIN COLLEGE OF MEDICINE, A DIVISION OF YESHIVA UNIVERSITY (US) 1992-12-23 WO disclosed
US-4774381-A TISSUE CULTURE SELECTION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-09-27 US disclosed
US-4675196-A ION EXCHANGE RESIN PIERRAL S.P.A. (IT) 1987-06-23 US disclosed
US-4579660-A Method for treatment of biomass EDINEN CENTAR PO CHIMIA (BG) 1986-04-01 US disclosed
US-4252822-A WITH VALINE, ISOLEUCINE, AND LEUCINE CHILDREN'S HOSPITAL MEDICAL CENTER (US) 1981-02-24 US disclosed
US-4209531-A SUPPLEMENTS OF VALINE, ISOLEUCINE AND LEUCINE CHILDREN'S HOSPITAL MEDICAL CENTER (US) 1980-06-24 US disclosed