Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388842 | 0.85 | DRD4 (0.38) | DRD4SIGMAR1DRD2KDRNPC1 | |
| SCHEMBL1388880 | 0.83 | DRD4 (0.45) | DRD4DRD2DRD3KDRPARP1 | |
| SCHEMBL1389022 | 0.82 | KDR (0.52) | DRD4SIGMAR1DRD2KDRHTR1A | |
| SCHEMBL1389027 | 0.79 | DRD4 (0.41) | DRD4DRD2DRD3KDRNPC1 | |
| SCHEMBL1389028 | 0.79 | DRD4 (0.41) | DRD4DRD2DRD3KDRNPC1 | |
| SCHEMBL1389143 | 0.77 | CD44 (0.49) | DRD4DRD2DRD3KDRPARP1 | |
| SCHEMBL1388929 | 0.73 | PARP1 (0.49) | DRD4DRD2DRD3KDRPARP1 | |
| SCHEMBL8984029 | 0.73 | SIGMAR1 (0.50) | DRD4SIGMAR1DRD2DRD3HTR1A | |
| SCHEMBL8299419 | 0.72 | DRD2 (0.38) | DRD4SIGMAR1DRD2DRD3PARP1 | |
| SCHEMBL8009072 | 0.70 | DRD4 (0.73) | DRD4SIGMAR1DRD2DRD3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717733-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | claimed |
| JP-H09502199-A | — | — | 1997-03-04 | — | — | JP | claimed |
| EP-0717733-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-06-26 | — | — | EP | claimed |
| WO-1995007262-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-16 | — | — | WO | claimed |
| EP-0717733-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| US-5686480-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0717733-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007262-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-16 | — | — | WO | disclosed |