SCHEMBL1389035

SCHEMBL1389035

CCC1=C(C)C(=Cc2[nH]c(-c3ccc[nH]3)cc2OC)N=C1C

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
EZH2 Q15910 2/20 0.33
TLK2 Q86UE8 1/20 0.32
PDGFRB P09619 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
MAPT P10636 1/20 0.30
CYP2C19 P33261 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1389034 1.00 EZH2 (0.33) EZH2TLK2PDGFRBCYP1A2CYP3A4
SCHEMBL7770883 0.91 CDK2 (0.33) MAPT
SCHEMBL7571849 0.91 CDK2 (0.33) MAPT
SCHEMBL31238321 0.87 GAA (0.33) EZH2TLK2CYP1A2CYP3A4MAPT
SCHEMBL19452944 0.84 ALDH1A1 (0.39) EZH2CYP1A2CYP3A4MAPTCYP2C19
SCHEMBL31237434 0.82 CYP1A2 (0.32) CYP1A2CYP3A4MAPTCYP2C19NPSR1
SCHEMBL19453005 0.81 KDM4E (0.37)
SCHEMBL31238363 0.76 MAPT (0.48) CYP1A2CYP3A4MAPTCYP2C19NPSR1
SCHEMBL3873740 0.74 EZH2 (0.32) EZH2TLK2PDGFRB
SCHEMBL3873747 0.74 EZH2 (0.32) EZH2TLK2PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0866701-B1 SYNERGISTIC IMMUNOSUPPRESSANT COMPOSITION CONTAINING A 2,2'-BI-1H-PYRROLE COMPOUND PHARMACIA & UPJOHN SPA (IT) 2002-01-16 EP claimed
EP-0825983-B1 PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES PHARMACIA & UPJOHN SPA (IT) 2001-08-29 EP claimed
EP-0825983-A1 PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES PHARMACIA & UPJOHN S.p.A. (IT) 1998-03-04 EP claimed
WO-1997030029-A1 PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES PHARMACIA & UPJOHN S.P.A. (IT) 1997-08-21 WO claimed
JP-H08507090-A 1996-07-30 JP claimed
EP-0686147-A1 NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY PHARMACIA & UPJOHN S.p.A. (IT) 1995-12-13 EP claimed
WO-1995017381-A1 NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY PHARMACIA S.P.A. (IT) 1995-06-29 WO claimed
EP-1241162-A1 2,2'-bi-1H-pyrrole derivatives with immunosuppressant activity Pharmacia Italia S.p.A. (IT) 2002-09-18 EP disclosed
EP-0866701-B1 SYNERGISTIC IMMUNOSUPPRESSANT COMPOSITION CONTAINING A 2,2'-BI-1H-PYRROLE COMPOUND PHARMACIA & UPJOHN SPA (IT) 2002-01-16 EP disclosed
US-6291509-B1 Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole compound PHARMACIA & UPJOHN SPA (IT) 2001-09-18 US disclosed
EP-0825983-B1 PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES PHARMACIA & UPJOHN SPA (IT) 2001-08-29 EP disclosed
EP-0825983-A1 PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES PHARMACIA & UPJOHN S.p.A. (IT) 1998-03-04 EP disclosed
US-5691334-A IMMUNOMODULATORS FOR SKIN GRAFTS, AUTOIMMUNE AND FOR ORGAN TRANSPLANTS PHARMACIA & UPJOHN S.P.A. (IT) 1997-11-25 US disclosed
WO-1997030029-A1 PROCESS FOR THE PREPARATION OF 2,2'-BIPYRROLYL-PYRROMETHENE (PRODIGIOSINS) DERIVATIVES PHARMACIA & UPJOHN S.P.A. (IT) 1997-08-21 WO disclosed
EP-0686147-A1 NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY PHARMACIA & UPJOHN S.p.A. (IT) 1995-12-13 EP disclosed
WO-1995017381-A1 NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY PHARMACIA S.P.A. (IT) 1995-06-29 WO disclosed