Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.45 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13998492 | 0.89 | GSK3B (0.64) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13885182 | 0.85 | GSK3B (0.58) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13998541 | 0.83 | GSK3B (0.71) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13998511 | 0.77 | GSK3B (0.67) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14012127 | 0.76 | GSK3B (0.49) | GSK3BCHEK1MAPKAPK2PLAT | |
| SCHEMBL12954291 | 0.75 | GSK3B (0.63) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL11930870 | 0.74 | CHEK1 (0.73) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13893796 | 0.74 | GSK3B (0.61) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13885060 | 0.74 | GSK3B (0.60) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13885183 | 0.74 | CHEK1 (0.56) | GSK3BCHEK1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514442-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |