Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14012147 | 0.89 | GSK3B (0.55) | GSK3BCHEK1MAPKAPK2ROCK1PLAT | |
| SCHEMBL13998492 | 0.87 | GSK3B (0.64) | GSK3BCHEK1MAPKAPK2ROCK1PLAT | |
| SCHEMBL13146410 | 0.79 | GSK3B (0.79) | GSK3BCHEK1 | |
| SCHEMBL13305175 | 0.77 | GSK3B (0.48) | GSK3BCHEK1 | |
| SCHEMBL13998541 | 0.77 | GSK3B (0.71) | GSK3BCHEK1MAPK1HTT | |
| SCHEMBL13893782 | 0.76 | GSK3B (0.57) | GSK3BCHEK1MAPKAPK2PLAT | |
| SCHEMBL13998511 | 0.74 | GSK3B (0.67) | GSK3BCHEK1 | |
| SCHEMBL14528738 | 0.74 | CHEK1 (0.56) | GSK3BCHEK1 | |
| SCHEMBL13305680 | 0.72 | GSK3B (0.55) | GSK3BCHEK1 | |
| SCHEMBL13885182 | 0.72 | GSK3B (0.58) | GSK3BCHEK1PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1534709-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-06-13 | — | — | EP | disclosed |