Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 4/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894039 | 0.89 | BTK (0.44) | BTKCLK2ITKKITSRC | |
| SCHEMBL13894038 | 0.88 | ITK (0.47) | BTKCLK2ITKKITSRC | |
| SCHEMBL13894040 | 0.86 | BTK (0.44) | BTKCLK2ITKKITSRC | |
| SCHEMBL13893959 | 0.86 | BTK (0.43) | BTKCLK2ITKKITSRC | |
| SCHEMBL13894012 | 0.78 | BTK (0.78) | BTKCLK2ITKSRCFLT3 | |
| SCHEMBL13894023 | 0.78 | BTK (0.67) | BTKCLK2 | |
| SCHEMBL13894056 | 0.75 | BTK (0.68) | BTKCLK2ITKSRCFLT3 | |
| SCHEMBL13893962 | 0.74 | BTK (0.41) | BTKCLK2ITKKDM4ELMNA | |
| SCHEMBL104965 | 0.74 | BTK (0.74) | BTKCLK2 | |
| SCHEMBL13894051 | 0.74 | BTK (0.67) | BTKCLK2SRCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |