Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 7/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 7/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893959 | 0.88 | BTK (0.43) | ITKKITSRCFLT3BTK | |
| SCHEMBL13893961 | 0.88 | BTK (0.48) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894039 | 0.87 | BTK (0.44) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894040 | 0.87 | BTK (0.44) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894117 | 0.86 | ITK (0.53) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894111 | 0.83 | BTK (0.53) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894122 | 0.79 | ITK (0.54) | ITKKITSRCFLT3BTK | |
| SCHEMBL13893962 | 0.76 | BTK (0.41) | ITKBTKCLK2KDM4ELMNA | |
| SCHEMBL13894051 | 0.76 | BTK (0.67) | SRCBTKCLK2KDM4E | |
| SCHEMBL13893960 | 0.75 | BTK (0.43) | ITKKITSRCFLT3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |