Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894017 | 0.84 | LMNA (0.43) | LMNAKDM4EPOLBBTKMAPT | |
| SCHEMBL13894014 | 0.82 | BTK (0.46) | LMNAKDM4EPOLBBTKTYK2 | |
| SCHEMBL13894015 | 0.80 | BTK (0.46) | LMNAKDM4EBTKMAPTPARP1 | |
| SCHEMBL13894021 | 0.80 | BTK (0.39) | LMNAKDM4EPOLBBTKTYK2 | |
| SCHEMBL13894019 | 0.78 | KDM4E (0.40) | LMNAKDM4EPOLBBTKMAPT | |
| SCHEMBL13893953 | 0.78 | NR1H4 (0.39) | LMNAKDM4EPOLBBTKMAPT | |
| SCHEMBL13893935 | 0.78 | BTK (0.45) | LMNAKDM4EPOLBBTKMAPT | |
| SCHEMBL13893892 | 0.75 | BTK (0.52) | BTKHPGD | |
| SCHEMBL13893934 | 0.75 | KDM4E (0.47) | LMNAKDM4EPOLBMAPTTYK2 | |
| SCHEMBL13893891 | 0.75 | BTK (0.61) | KDM4EBTKTYK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |