Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893892 | 0.92 | BTK (0.52) | BTKCLK2 | |
| SCHEMBL13894043 | 0.90 | BTK (0.49) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL13894046 | 0.89 | BTK (0.67) | BTK | |
| SCHEMBL12602968 | 0.88 | KDM4E (0.55) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL13894025 | 0.86 | BTK (0.67) | BTKKDM4ERAB9ACLK2 | |
| SCHEMBL13893945 | 0.86 | RAB9A (0.56) | BTKKDM4ERAB9ACLK2TYK2 | |
| SCHEMBL13894015 | 0.86 | BTK (0.46) | BTKKDM4ERAB9A | |
| SCHEMBL13893950 | 0.83 | BTK (0.48) | BTKCLK2 | |
| SCHEMBL15906458 | 0.82 | BTK (0.72) | BTK | |
| SCHEMBL13894284 | 0.82 | BTK (0.58) | BTKKDM4ERAB9ACLK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |